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Clinical Trial Summary

This phase 2 trial will test whether the combination of DaraRd (daratumumab + lenalidomide + dexamethasone) as induction therapy, followed by DRVd (daratumumab + lenalidomide + bortezomib + dexamethasone) consolidation therapy, if needed, will result in more patients achieving minimal residual disease (MRD)-negative status, relative to the standard of care. Consolidation therapy will be administered only to those patients with MRD-positive status after induction therapy. This is a study based on adaptive design for decision making of treatment options. Duration of therapy (daratumumab cycles) will depend on individual approach, response, evidence of disease progression and tolerance.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04140162
Study type Interventional
Source University of Michigan Rogel Cancer Center
Contact
Status Active, not recruiting
Phase Phase 2
Start date October 5, 2020
Completion date August 2026

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