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Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma — KarMMa  

Multiple Myeloma Clinical Trial

Official title:
A Phase 2, Multicenter Study to Determine the Efficacy and Safety of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma

Clinical Trial Summary

This is an open label, single-arm, multicenter, Phase 2 study to evaluate the efficacy and safety of bb2121 in subjects with relapsed and refractory multiple myeloma. A leukapheresis procedure will be performed to manufacture bb2121 chimeric antigen receptor (CAR) modified T cells. Prior to bb2121 infusion subjects will receive lymphodepleting therapy with fludarabine and cyclophosphamide.

Clinical Trial Description

Anti-myeloma bridging treatment is allowed for disease control while bb2121 is being manufactured. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03361748
Study type Interventional
Source Celgene
Contact
Status Completed
Phase Phase 2
Start date December 18, 2017
Completion date December 20, 2023
View Details
See also
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