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Study to Assess Safety, Tolerability, Pharmacokinetics and Antitumor Activity of AZD4573 in Relapsed/Refractory Haematological Malignancies

Multiple Myeloma Clinical Trial

Official title:
A Phase 1, Open-Label, Multicentre, Non-Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of AZD4573, a Potent and Selective CDK9 Inhibitor, in Subjects With Relapsed or Refractory Haematological Malignancies

Clinical Trial Summary

The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary antitumor activity of AZD4573 in subjects with relapsed or refractory haematological malignancies.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Acute Lymphocytic Leukemia
  • Acute Myeloid Leukemia
  • B-cell Non-Hodgkin Lymphoma
  • Chronic Lymphocytic Leukemia
  • Chronic Myelomonocytic Leukemia
  • Hematologic Neoplasms
  • High Risk Myelodysplastic Syndrome
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Leukemia, Myeloid, Acute
  • Leukemia, Myelomonocytic, Chronic
  • Leukemia, Myelomonocytic, Juvenile
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, Non-Hodgkin
  • Lymphoma, T-Cell
  • Multiple Myeloma
  • Myelodysplastic Syndromes
  • Neoplasms
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Preleukemia
  • Relapsed or Refractory Haematological Malignancies Including
  • Richter's Syndrome
  • Small Lymphocytic Lymphoma
  • Syndrome
  • T-cell Non-Hodgkin Lymphoma
Clinical Trial Details
NCT number NCT03263637
Study type Interventional
Source AstraZeneca
Contact
Status Completed
Phase Phase 1
Start date October 24, 2017
Completion date September 30, 2021
View Details
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