Multiple Myeloma Clinical Trial
Official title:
Vaccination With PD-L1 Peptide With Montanide Against Multiple Myeloma After High Dose Chemotherapy With Stem Cell Support. A Phase I First-in-human Study.
Title: Vaccination with PD-L1 peptide with Montanide against multiple myeloma after high dose
chemotherapy with stem cell support. A phase I first-in-human study.
Hypothesis: In this trial the investigators assess a new immunotherapeutic strategy targeting
the immune checkpoint molecule PD-L1 to investigate the potential of vaccination against
PD-L1 as a possible anticancer target.
Background: Multiple myeloma is the second most common hematologic cancer which is despite
advances in treatment is still incurable for most patients.
In this trial the investigators assess a new immunotherapeutic strategy targeting the immune
checkpoint molecule PD-L1 to investigate the potential of vaccination against PD-L1 as a
possible anticancer target.
PD-L1 has been recognized as an important factor in immune regulation and development of
immune tolerance in the microenvironment of cancer cells. Cells that express PD-L1 on their
surface are known to inhibit the immune system. As seen with the recent advances in
immunotherapy against cancer with antibodies against PD-L1, the the immunosuppressive role of
the molecule PD-L1 can be antagonized to the benefit of patients with cancer. PD-L1 is
expressed on both cancer cells, antigen presenting cells and immunosuppressive cells in the
tumor micro-environment. Vaccination against PD-L1 is therefore two sided. The investigators
aim to stimulate PD-L1 specific T-cells, hence eliminating both PD-L1 positive tumor cells as
well as PD-L1 positive immunosuppressive and antigen presenting cells in the tumor
microenvironment. The primary endpoints are safety and toxicity evaluation. Secondary
endpoint is immunological response. Clinical response will be described.
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