Multiple Myeloma Clinical Trial
Official title:
Clinical Significance of CX3CR1 Adhesion Molecule-expressing Myeloid and Lymphoid Cells in Hematologic Malignancy
This study evaluates the clinical significance of CX3CR1-expressing myeloid and lymphoid
cells in patients of hematologic malignancy.
Tumor cells either express membrane molecules or release tumor-derived soluble factors able
to alter myelopoiesis and lymphopoiesis. Myeloid cells expressing CD11b play a critical role
in sustaining cancer progression. Also, the fractalkine (CX3CL1; Fkn)/CX3CR1 axis plays an
important function in the pathophysiology of various forms of cancers. Fkn is the only known
ligand for CX3CR1, and it triggers recruitment of CX3CR1-positive cells through its unique
receptor, CX3CR1. Therefore, the investigators focused the prognostic significance of CD11b+
myelo-monocytic cells expressing CX3CR1 and CD3+ lymphoid cells expressing CX3CR1 in the
clinical outcomes of newly diagnosed Diffuse Large B-cell Lymphoma (DLBCL) and Multiple
myeloma (MM).
| Status | Recruiting |
| Enrollment | 50 |
| Est. completion date | August 2021 |
| Est. primary completion date | August 2019 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Subject newly diagnosed multiple myeloma. - Subject newly diagnosed diffuse large B cell lymphoma. Exclusion Criteria: - History of other hematologic malignancy - History of previous chemotherapy |
| Country | Name | City | State |
|---|---|---|---|
| Korea, Republic of | The Catholic University of Korea, St.Vincent's hospital | Suwon-si | Gyeonggi-do |
| Lead Sponsor | Collaborator |
|---|---|
| Saint Vincent's Hospital, Korea |
Korea, Republic of,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | progression free survival | 3 years | ||
| Secondary | overall survival | 3 years | ||
| Secondary | Death | 3 years |
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