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Trial of Carfilzomib, Lenalidomide, Dexamethasone Versus Lenalidomide Alone After Stem-cell Transplant for Multiple Myeloma

Multiple Myeloma Clinical Trial

Official title:
Phase 3 Randomized Trial of Carfilzomib, Lenalidomide, Dexamethasone Versus Lenalidomide Alone After Stem-cell Transplant for Multiple Myeloma

Clinical Trial Summary

This is a Phase 3 randomized trial of carfilzomib, lenalidomide, dexamethasone versus lenalidomide alone after stem-cell transplant for multiple myeloma, eligible to subjects who completed autologous stem cell transplant for symptomatic myeloma who are considered for lenalidomide maintenance.

Clinical Trial Description

Primary Objective: - To compare progression free survival between Kyprolis (Carfilzomib), Revlimid (lenalidomide), Dexamethasone (KRd) arm and lenalidomide arm Secondary Objectives - To determine the rate of minimal residual negative disease (MRD) at 6 and 12 months after randomization - To compare the efficacy (rate of partial response, very good partial response, complete response, and stringent complete response) of KRd vs. Lenalidomide alone after randomization ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02659293
Study type Interventional
Source University of Chicago
Contact
Status Active, not recruiting
Phase Phase 3
Start date April 26, 2016
Completion date November 2026
View Details
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