Multiple Myeloma Clinical Trial
Official title:
A Phase I Trial of the MUC1 Inhibitor, GO-203-2c, in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma
This research study is studying a combination of targeted therapies known as GO-203-2C and bortezomib as a possible treatment for multiple myeloma that has either progressed or not responded to treatment.
This research study is a Phase I clinical trial, which tests the safety of an investigational
intervention and also tries to define the appropriate dose of the investigational
intervention to use for further studies. "Investigational" means that the intervention is
being studied.
The FDA (the U.S. Food and Drug Administration) has not approved GO-203-2C as a treatment for
any disease.
The FDA (the U.S. Food and Drug Administration) has approved bortezomib as a treatment option
for your disease.
The purpose of this research study is to test the safety of GO-203-2C with bortezomib.
GO-203-2C is a newly discovered compound that binds to an oncoprotein (a cancer causing
protein) called MUC1. Myeloma cells harbor an increased amount of MUC1 on its cell surface.
By binding to MUC1, GO-203-2C has been shown to cause tumor cell death in laboratory studies.
Bortezomib is an intravenously or subcutaneously administered medication that belongs to a
class of drugs called proteasome inhibitors. Proteasome inhibitors disrupt the normal action
of cells that breakdown proteins in both normal and cancer cells. This disruption can stall
tumor growth and cause cancer cells to die. Bortezomib is currently approved for the
treatment of multiple myeloma.
The Investigators want to find the highest dose of GO-203-2C given in combination with
bortezomib that can be administered safely without severe or unmanageable side effects.
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