Multiple Myeloma Clinical Trial
Official title:
An Open-Label Phase IV Study of the Efficacy of Bortezomib-based Combination Therapy the Treatment of Subjects With Multiple Myeloma
To investigate the efficacy of a modified bortezomib based combination therapy for patients with multiple myeloma.
Multiple myeloma (MM) is a common hematological malignancy in Chinese elderly population. The
application of novel drugs improved the clinical outcome and survival of MM patients,even
though MM remains an incurable hematological malignancy. Bortezomib is a typical one among
these novel agents, its application resulted in great success, but its adverse events and
high expense restricted its widely usage. Investigators modified the dose and frequency of
bortezomib administration in combination therapy: Patients in the modified group received
regimen with bortezomib (1.6mg/㎡) as an intravenous bolus once weekly on day 1, 8 in a 3
weeks cycle, in combination with dexamethasone,with or without doxorubicin/
cyclophosphamide/mitoxsnteone/thalidomide，while patients in the control group received
similar combination therapy except with conventional bortezomib (1.3mg/㎡) administration
twice weekly on day 1,4, 8,11.
The aim of this study is to investigate whether the modified bortezomib-based therapy may
attain a similar efficacy as the conventional ones.
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