| Eligibility |
Inclusion Criteria
1. Subjects must have a confirmed prior diagnosis of active MM as defined by the updated
IMWG criteria101..
2. Subjects must have relapsed or refractory disease after either one of the following:
1. At least 3 prior regimens, which must have contained an alkylating agent,
proteasome inhibitor, and immunomodulatory agent (IMiD).
OR
2. At least 2 prior regimens if "double-refractory" to a proteasome inhibitor and
IMiD, defined as progression on or within 60 days of treatment with these agents.
Note: Induction therapy, stem cell transplant, and maintenance therapy, if given
sequentially without intervening progression, should be considered as 1 "regimen".
3. Subjects must have signed written, informed consent.
4. Subjects must be = 18 years of age.
5. Subjects must be at least 90 days since autologous or allogeneic stem cell transplant,
if performed.
6. Subjects must have adequate vital organ function:
1. Serum creatinine = 2.5 or estimated creatinine clearance =30 ml/min and not
dialysis-dependent.
2. Absolute neutrophil count =1000/µl and platelet count =50,000/µl (=30,000/µl if
bone marrow plasma cells are =50% of cellularity).
3. SGOT = 3x the upper limit of normal and total bilirubin = 2.0 mg/dl (except for
patients in whom hyperbilirubinemia is attributed to Gilbert's syndrome).
4. Left ventricular ejection fraction (LVEF) = 45%. LVEF assessment must have been
performed within 8 weeks of enrollment.
5. Toxicities from prior therapies, with the exception of peripheral neuropathy
attributable to bortezomib, must have recovered to grade = 2 according to the CTC
4.0 criteria or to the subject's prior baseline.
7. Subjects must have an ECOG performance status of 0-2.
8. Subjects must have measurable disease on study entry, which must include at least 1 of
the following:
1. Serum M-spike = 0.5 g/dL*
2. 24 hr urine M-spike = 200mg
3. Involved serum FLC = 50 mg/L with abnormal ratio
4. Measurable plasmacytoma on exam or imaging
5. Bone marrow plasma cells = 20% (bone marrow biopsy only required at screening if
no other measurable disease is present).
- Note: Patients with IgA myeloma in whom serum protein electrophoresis is
deemed unreliable, due to co-migration of normal serum proteins with the
paraprotein in the beta region, may be considered eligible as long as total
serum IgA level is elevated above normal range.
9. Subjects of reproductive potential must agree to use acceptable birth control methods.
IMWG Criteria for Diagnosis of Multiple Myeloma Presence of an M-component in serum and/or
urine plus clonal plasma cells in the bone marrow and/or a documented clonal plasmacytoma.
In patients with no detectable M-component, an abnormal serum FLC ratio on the serum FLC
assay can substitute and satisfy this criterion. For patients, with no serum or urine
M-component and normal serum FLC ratio, the baseline bone marrow must have =10% clonal
plasma cells; these patients are referred to as having 'non-secretory myeloma'. Patients
with biopsy-proven amyloidosis and/or systemic light chain deposition disease (LCDD) should
be classified as 'myeloma with documented amyloidosis' or 'myeloma with documented LCDD,'
respectively if they have =30% plasma cells and/or myeloma-related bone disease.
PLUS one or more of the following, which must be attributable to the underlying plasma cell
disorder:
- Calcium elevation (>11.5 mg/dl)
- Renal insufficiency (creatinine >2 mg/dl)
- Anemia (hemoglobin <10 g/dl or at 2 g/dl below normal)
- Bone disease (lytic lesions or osteopenia) OR one of the following "myeloma-defining
events"
- Bone marrow plasma cells =60% of cellularity
- Serum free kappa:lambda ratio =100:1 (or =1:100), with involved free light chain =100
mg/L
- More than 1 focal bone lesion on MRI
Exclusion Criteria
- Be pregnant or lactating.
- Have inadequate venous access for or contraindications to leukapheresis.
- Have any active and uncontrolled infection.
- Have active hepatitis B, hepatitis C, or HIV infection.
- Any uncontrolled medical or psychiatric disorder that would preclude participation as
outlined.
- Have NYHA Class III or IV heart failure, unstable angina, or a history of recent
(within 6 months) myocardial infarction or sustained (>30 seconds) ventricular
tachyarrhythmias.
- Have received prior gene therapy or gene-modified cellular immunotherapy. Subject may
have received, however, non-gene-modified autologous T-cells in association with an
anti-myeloma vaccine (e.g., hTERT or MAGEA3) or vaccination against infectious agents
(e.g., influenza or pneumococcus) as was performed on our previous studies.
- Have active auto-immune disease, including connective tissue disease, uveitis,
sarcoidosis, inflammatory bowel disease, or multiple sclerosis, or have a history of
severe (as judged by the principal investigator) autoimmune disease requiring
prolonged immunosuppressive therapy.
- Have a history of neurodegenerative or central nervous system movement disorder.
- Have prior or active central nervous system (CNS) involvement (e.g. leptomeningeal
disease, parenchymal masses) with myeloma. Screening for this (e.g. with lumbar
puncture) is not required unless suspicious symptoms or radiographic findings are
present. Subjects with calvarial disease that extends intracranially and involves the
dura will be excluded, even if CSF is negative for myeloma.
- Have active acute or chronic graft-versus-host-disease (GVHD), or require
immunosuppressant medications for GVHD, within 4 weeks of enrollment.
|
