Multiple Myeloma Clinical Trial
Official title:
"Monoclonal Antibodies for Treatment of Multiple Myeloma. Present Status and Aspects of Effector Mechanisms With Emphasis on the CD38 Antibody Daratumumab "
Daratumumab is a new treatment for patients with myeloma. While many patients benefit from this treatment some do not and the mechanism(s) of failure are poorly understood. This study aims to clarify aspects of resistance to treatment with daratumumab in order to improve patient outcomes in the future.
The effector mechanisms of daratumumab have been extensively studied in vitro, but the in
vivo correlates and key determinants of success or failure when daratumumab is used alone or
in combination with lenalidomide for treatment of patients with myeloma have not been
clarified.
There is potentially a wide spectrum of factors that may influence the quality and duration
of response following treatment with daratumumab. The integrity of the patient's immune
system may be important. Prior lines of chemotherapy or the myeloma disease itself may impair
humural (i.e. complement) or cellular (i.e. ADCC) effector mechanisms that are of importance
for the response to daratumumab. Also intrinsic properties of the tumor cells or interactions
between myeloma cells and the bone marrow microenvironment could make the myeloma cells
refractory to daratumumab.
A better understanding of these variables may enable us to improve the quality and duration
of daratumumab-induced responses and make daratumumab-based therapies more effective in the
near future.
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|---|---|---|---|
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