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Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies

Multiple Myeloma Clinical Trial

Official title:
Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies

Clinical Trial Summary

New conditioning regimens are still needed to maximize efficacy and limit treatment-related deaths of allogeneic transplantation for advanced hematologic malignancies. Over the past several years, the investigators have evaluated several new conditioning regimens that incorporate fludarabine, a novel immunosuppressant that has limited toxicity and that has synergistic activity with alkylating agents. Recent data have suggested that fludarabine may be used in combination with standard doses of oral or IV busulfan, thus reducing the toxicity previously observed with cyclophosphamide/ busulfan regimens.

Clinical Trial Description

Treatment-related mortality and recurrence of disease account for the majority of treatment failures in allogeneic transplantation for advanced hematologic malignancies. The most commonly utilized conditioning regimens consist of cyclophosphamide and total-body irradiation or busulfan and cyclophosphamide. Other agents such as etoposide or thiotepa are sometimes added to maximize the antileukemic effect. New conditioning regimens are however still needed to maximize efficacy and limit treatment-related deaths. Over the past several years, the investigators have evaluated several new conditioning regimens that incorporate fludarabine, a novel immunosuppressant that has limited toxicity and that has synergistic activity with alkylating agents. Recent data have suggested that fludarabine may be used in combination with standard doses of oral or IV busulfan, thus reducing the toxicity previously observed with cyclophosphamide/ busulfan regimens. ;

Study Design

Related Conditions & MeSH terms

  • Acute Leukemia
  • Acute Myeloid Leukemia
  • Anemia, Aplastic
  • Aplastic Anemia
  • Chronic Myelogenous Leukemia
  • Hodgkin Disease
  • Hodgkin's Disease
  • Leukemia
  • Leukemia, Lymphoid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Leukemia, Myeloid, Acute
  • Lymphocytic Leukemia
  • Lymphoma
  • Malignant Lymphoma
  • Multiple Myeloma
  • Myelofibrosis
  • Myeloproliferative Disorder
  • Myeloproliferative Disorders
  • Neoplasms, Plasma Cell
  • Polycythemia
  • Polycythemia Vera
  • Primary Myelofibrosis
Clinical Trial Details
NCT number NCT01499147
Study type Interventional
Source University of Illinois at Chicago
Contact
Status Completed
Phase N/A
Start date February 2000
Completion date May 2013
View Details
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