Multiple Myeloma Clinical Trial
Official title:
Pilot Trial of Fractionated Stem Cell Infusions in Myeloma Patients Undergoing Autologous Stem Cell Transplant
Multiple myeloma is difficult to treat with only anti-cancer medicine (called chemotherapy)
or radiation alone. Sometimes higher doses of chemotherapy are used but when used can also
lower blood counts. Using own cells (special cells called stem cells) to help increase the
blood counts after high doses of chemotherapy is called autologous stem cell transplantation
(ASCT).
Using own stem cells to restore blood counts and other advances in supportive measures
(antibiotics and growth factors that increase blood counts) has improved the safety of ASCT.
However, blood counts still decrease for a period of days after high doses of chemotherapy.
During that time, patients are at greater risk for infections. Studies have shown that the
faster the blood counts recover after ASCT, the less at risk there is for developing
unwanted side effects after ASCT.
Typically during an ASCT, a patient's stem cells are given back to them all at once on a
single day. In this study, the investigators plan to see what happens when smaller amounts
of own stem cells are given back to the patient over multiple days. The investigators want
to find out what effects good and/or bad this will have on the patient and there multiple
myeloma. Some studies have shown that giving back stem cells over a period of days helps to
increase bone marrow activity and decrease the time it takes for blood counts to recover
after ASCT. It is our hope that this new approach may lower a patient's risk of side effects
and infections, decrease the number of blood transfusions that a patient needs during this
process, reduce the time a patient has to spend in the hospital, and lower overall treatment
costs.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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