MULTIPLE MYELOMA Clinical Trial
Official title:
UARK 2005-05, Coagulation-Related Effects of Velcade Treatment in Patients With Relapsed or Refractory Multiple Myeloma
To evaluate changes in coagulation (blood clotting) factors and platelet function in multiple myeloma participants undergoing VELCADE treatment for the first time.
Cardiovascular complications during the treatment of patients with multiple myeloma are not
uncommon, (10%) and the frequency clearly increases with the use of regimens containing
thalidomide in combination with glucocorticosteroids or chemotherapy especially adriamycin.
Even with prophylactic anticoagulation, DVT still occurs in 10% of such patients. The use of
full anticoagulation raises considerable concern of bleeding especially during the post
chemotherapy thrombocytopenic period. We observed no thromboembolic episodes when Velcade
was added to thalidomide and adriamycin containing chemotherapy.
Therefore, we would like to investigate this protective antithrombotic effect of VELCADE in
a malignancy associated with a hypercoagulable state in a group of 10 patients with
Relapsed/Refractory Multiple Myeloma.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label
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