Multiple Myeloma Clinical Trial
Official title:
A Study of Intensive-Dose Melphalan and Topotecan (MT) Followed by Autologous Stem Cell Rescue in Patients With Multiple Myeloma.
The purpose of this research study is to determine the safest dose of topotecan when given in a high dose before a stem cell transplant; topotecan will be given with melphalan.
The stem cells being transplanted are cells found in the bone marrow and blood that are
responsible for making red blood cells, white blood cells, and platelets. The stem cells are
collected by a process called leukapheresis and will be frozen for later use. After receiving
the chemotherapy drugs, the stem cells will be thawed and given like a blood transfusion.
This is called autologous stem cell transplant or rescue. The study doctors will be measuring
how well the disease responds to the drugs as well as any side effects to the drugs. During
the course of this study, blood and bone marrow samples will be obtained to measure levels of
the chemotherapy drugs as well as levels of certain enzymes (proteins).
The staff of the Blood and Marrow Transplant program will continue to collect information
about the participant's disease and its treatment for the rest of their life.
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