Multiple Myeloma Clinical Trial
Multiple myeloma is a disorder in which malignant plasma cells accumulate in the bone
marrow. These plasma cells produce an abnormal protein called paraprotein / M spike in the
serum which can be serially monitored to assess the response of tumour on therapy. The
paraprotein has a heavy chain which can be either IgG, IgA, IgM or IgD and a light chain
which can be either kappa or lambda.
At present, these can be assessed by serum and urine electrophoresis (SPE and UPE). These
techniques are relatively insensitive and poorly quantitative compared with other
immunoassays for tumour markers.
The potential of serum free light chain (flc) measurement as a marker for myeloma has been
recognised for some time. However, development of such assays has proved elusive, primarily
due to the difficulty in developing assays that are both convenient to use and have the
required specificity to measure flc in serum. Recently , the assay has been standardised and
is in use. Its likely that the assessment of flc might be a sensitive marker of documenting
complete remission in patients with myeloma. The aim of this study is to study the flc in
patients with myeloma in complete remission (CR) to see if patients have CR documented by
standard criteria- are the free light chains still positive and if so are they better
markers of remission. The samples will be collected and tested in batches of 60 each.
Status | Completed |
Enrollment | 0 |
Est. completion date | December 2005 |
Est. primary completion date | |
Accepts healthy volunteers | |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Multiple Myeloma patients in CR Exclusion Criteria: - not being able to give consent |
Allocation: Random Sample, Time Perspective: Longitudinal
Country | Name | City | State |
---|---|---|---|
United Kingdom | Royal Marsden NHS trust | Sutton | Surrey |
Lead Sponsor | Collaborator |
---|---|
Royal Marsden NHS Foundation Trust |
United Kingdom,
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