Multiple Myeloma Clinical Trial
Official title:
A Novel Vaccine for the Treatment of MUC1-expressing Tumor Malignancies
NCT number | NCT00162500 |
Other study ID # | 191203-HMO-CTIL |
Secondary ID | |
Status | Withdrawn |
Phase | Phase 2 |
First received | September 11, 2005 |
Last updated | November 9, 2010 |
Rationale:
ImMucin was shown to be able to induce a robust cellular immune response mediated via both
CD4+ and CD8+ T lymphocytes and therefore, could potentially be more effective in the
majority of the target population.
Purpose:
The purpose of this study is to evaluate the safety and initial efficacy of ImMucin, a novel
peptide vaccine in metastatic tumors expressing the MUC-1 Tumor Associated Antigen (TAA).
Status | Withdrawn |
Enrollment | 15 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - All patients must have a histological or cytological diagnosis of metastatic disease expressing the MUC-1. Patients must have metastatic disease and have failed at least one regimen of standard based chemotherapy for metastatic disease such as: - Renal Cell Carcinoma (RCC), - Transitional Cell Carcinoma (TCC), - Prostate, - Breast, - Ovary, - Non-small cell lung, - Colon, - Multiple myeloma and - Pancreatic. - Patients must be >18 years of age, consenting to participation in the study. - Patients must have at least one site of measurable tumor or measurable tumor marker. Exclusion Criteria: - Patients receiving any immunosuppressive treatment that could negate development of an effective immune response to the vaccine. - Subjects with prior irradiation to a field that includes more than 25% of their lymph nodes and bone marrow likely to be immunosuppressed will be excluded. However, patients who had standard pelvic field radiation such as adjuvant therapy for rectal cancer are not excluded. - Pregnant and breast feeding women will be excluded. Premenopausal women who are not practicing or willing to practice adequate birth control methods for a period of 3 months after treatment will be excluded. - Patients with brain metastases. - Patients with active infection. - Patients with HIV hepatitis B surface antigen (HBS Ag) and hepatitis C virus (HCV) positive patients. |
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Israel | Hadassah Medical Organization | Jerusalem |
Lead Sponsor | Collaborator |
---|---|
Hadassah Medical Organization | Vaxil Therapeutics Ltd. |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determine the safety and tolerability of vaccination comprising the ImMucin vaccine | |||
Primary | combined with Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), in patients | |||
Primary | with multiple myeloma and other MUC-1 antigen-expressing metastatic carcinomas | |||
Secondary | Determine objective anti-tumor response in patients treated with this regimen; | |||
Secondary | Determine immune response in patients treated with this regimen |
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