Multiple Myeloma, Refractory Clinical Trial
Official title:
Phase I Study to Evaluate the Safety and Effectiveness of Anti-BCMA CAR-NK Therapy in Relapsed or Refractory Multiple Myeloma
The purpose of this study is to infuse BCMA CAR-NK cells(Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells) to the patients with relapsed and refractory multiple myeloma (MM), to assess the safety and feasibility of this strategy. The CAR enables the NK cells to recognize and kill the MM cells by targeting of BCMA, a protein expressed of the surface of the malignant plasma cells in MM patients.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT06411301 -
A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors
|
Phase 1 | |
Recruiting |
NCT06158412 -
All-trans Retinoic Acid in Combination With a KPD Regimen for the Treatment of Refractory/Relapsed Multiple Myeloma
|
Phase 2 | |
Recruiting |
NCT05121103 -
A Study of the Safety, Tolerability and Effectiveness of EZM0414 Investigative Product in Participants With Relapsed/Refractory Multiple Myeloma and Relapsed/Refractory Diffuse Large B Cell Lymphoma
|
Phase 1 | |
Recruiting |
NCT04603872 -
CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Hematological Malignancies
|
Early Phase 1 | |
Recruiting |
NCT04657861 -
APRIL CAR-T Cell Therapy for Patients With BCMA/TACI Positive Relapsed and/or Refractory Multiple Myeloma
|
Early Phase 1 | |
Terminated |
NCT05191472 -
Pembrolizumab for the Treatment of Relapsed or Refractory Multiple Myeloma After Anti-BCMA CAR-T Therapies
|
Phase 2 | |
Active, not recruiting |
NCT04688853 -
A Study to Investigate the Safety and Efficacy of TEG002 in Relapsed/Refractory Multiple Myeloma Patients
|
Phase 1 | |
Not yet recruiting |
NCT05050305 -
Marizomib Central Nervous System (CNS)
|
Phase 2 | |
Recruiting |
NCT05546723 -
LMY-920 for Treatment of Relapsed or Refractory Myeloma
|
Phase 1 | |
Not yet recruiting |
NCT06225310 -
A Trial of Selinexor, Ruxolitinib and Methylprednisolone
|
Phase 1 | |
Not yet recruiting |
NCT06115135 -
A Study of Venetoclax in Combination With Isatuximab and Dexamethasone for Relapsed/Refractory Multiple Myeloma
|
Phase 2 | |
Recruiting |
NCT05673083 -
Impact of a Health Technology Intervention on Patient Activation in Multiple Myeloma
|
||
Completed |
NCT02176213 -
Study of Pomalidomide, Cyclophosphamide, Dexamethasone in Relapsed/Refractory Multiple Myeloma
|
Phase 2 | |
Enrolling by invitation |
NCT04861480 -
Dual-target CAR-T Cells (C-4-29) in the Treatment of Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
Completed |
NCT06012383 -
Alvocade® (Bortezomib) Safety and Effectiveness Study
|
||
Not yet recruiting |
NCT05909826 -
Carfilzomib, Oral Cyclophosphamide, and Dexamethasone for RRMM
|
Phase 2 | |
Recruiting |
NCT04414475 -
A Study of Selinexor (Seli) + Low-dose Dexamethasone (LDD) in Penta-refractory Multiple Myeloma (MM), Seli and Bortezomib + LDD in Triple-class Refractory MM, and Seli and Pomalidomide + LDD in Relapsed Refractory MM
|
Phase 2 | |
Completed |
NCT04811898 -
A Dose Escalation Study of LNA-i-Mir-221 for Cancer Treatment
|
Phase 1 | |
Recruiting |
NCT05739188 -
Safety and Efficacy of Anti-GPRC5D CAR-T Cells Therapy in the Treatment of r/r MM
|
Phase 1/Phase 2 | |
Recruiting |
NCT05747586 -
BCMA CAR-NK For Patients With RRMM
|
N/A |