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Clinical Trial Summary

It is a single-center, open-labeled, single-arm, non-randomized investigatorinitiated trial evaluating the efficacy and safety of anti-GPRC5D CAR-T cells therapy for relapsed and refractory(r/r) multiple myeloma(MM) after three or more lines of treatments.


Clinical Trial Description

This open label, single-arm, investigator-initiated study aims to evaluate the efficacy and safety of Anti-GPRC5D CAR-T in subjects with relapsed and refractory(r/r) multiple myeloma(MM) after three or more lines of treatments. A leukapheresis procedure will be performed to manufacture Anti-GPRC5D chimeric antigen receptor (CAR) modified T cells. Prior to Anti-GPRC5D CAR-T cells infusion subjects will receive lymphodepleting therapy with fludarabine and cyclophosphamide. After infusion, the safety and efficacy of CAR-T therapy was evaluated by investigators. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05749133
Study type Interventional
Source Institute of Hematology & Blood Diseases Hospital
Contact Yan Xu, MD
Phone 13920593907
Email xuyan1@ihcams.ac.cn
Status Recruiting
Phase Phase 1/Phase 2
Start date April 10, 2023
Completion date December 2025

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