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Safety and Efficacy of Anti-GPRC5D CAR-T Cells Therapy in the Treatment of r/r MM

Multiple Myeloma in Relapse Clinical Trial

Official title:
An Investigator-initiated Trial Evaluating the Efficacy and Safety of Anti-GPRC5D CAR-T Cells Therapy in the Treatment of Relapsed / Refractory(r/r) Multiple Myeloma(MM)

Clinical Trial Summary

It is a single-center, open-labeled, single-arm, non-randomized investigator-initiated trial evaluating the efficacy and safety of anti-GPRC5D CAR-T cells therapy for relapsed and refractory(r/r) multiple myeloma(MM).

Clinical Trial Description

This open label, single-arm, Phase I study aims to evaluate the efficacy and safety of Anti-GPRC5D CAR-T in subjects with relapsed and refractory(r/r) multiple myeloma(MM). A leukapheresis procedure will be performed to manufacture Anti-GPRC5D chimeric antigen receptor (CAR) modified T cells. Prior to Anti-GPRC5D CAR-T cells infusion subjects will receive lymphodepleting therapy with fludarabine and cyclophosphamide. After infusion, the safety and efficacy of CAR-T therapy was evaluated by investigators. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05739188
Study type Interventional
Source 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
Contact Sanbin Wang, MD
Phone 13187424131
Email Sanbin1011@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date February 7, 2023
Completion date December 31, 2025
View Details
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