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Clinical Trial Summary

This is a multicenter, open-label, Phase 1B/2 study to evaluate the safety and assess the preliminary anti-tumor activity of binimetinib administered in combination with nivolumab or nivolumab + ipilimumab in adult patients with advanced metastatic colorectal cancer (mCRC) with microsatellite stable (MSS) disease and presence of a RAS mutation that have received at least one prior line of therapy and no more than 2 prior lines of therapy. The study contains a Phase 1b period to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) and schedule of binimetinib followed by a randomized Phase 2 period to assess the efficacy of the combinations.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03271047
Study type Interventional
Source Pfizer
Contact
Status Completed
Phase Phase 2
Start date October 18, 2017
Completion date February 25, 2021

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