NCT04104178 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

6
Henius AE, Pedersen K, Jensen LB. Danmap 2017. 2017
Authority DH
Guidance on Preventing the Spread of MRSA. December 13. 2016. p. ISBN online: 978-87-7104-854-4
Bagge K, Benfield T, Westh H, Bartels MD
Eradicating MRSA carriage: the impact of throat carriage and Panton-Valentine leukocidin genes on success rates. Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):683-688. doi: 10.1007/s10096-019-03474-6. Epub 2019 Jan 25.
JEVONS MP, COE AW, PARKER MT
Methicillin resistance in staphylococci. Lancet. 1963 Apr 27;1(7287):904-7. doi: 10.1016/s0140-6736(63)91687-8. No abstract available.
Kluytmans J, van Belkum A, Verbrugh H
Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev. 1997 Jul;10(3):505-20. doi: 10.1128/CMR.10.3.505.
Lowy FD
Staphylococcus aureus infections. N Engl J Med. 1998 Aug 20;339(8):520-32. doi: 10.1056/NEJM199808203390806. No abstract available.
VandenBergh MF, Yzerman EP, van Belkum A, Boelens HA, Sijmons M, Verbrugh HA
Follow-up of Staphylococcus aureus nasal carriage after 8 years: redefining the persistent carrier state. J Clin Microbiol. 1999 Oct;37(10):3133-40. doi: 10.1128/JCM.37.10.3133-3140.1999.

A Randomized Placebo-controlled Double-blinded Trial of the Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin

Details for clinical trial NCT04104178

Clinical trial NCT04104178 - References