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NCT05343104 Clinical Trial

Osteoarthrosis on 7.0T Magnetic Resonance Imaging

MRI Clinical Trial

Official title:
Osteoarthrosis on 7.0T Magnetic Resonance Imaging

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05343104
Other study ID # Osteoarthrosis-ChinaPLAGH
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 1, 2022
Est. completion date May 31, 2025

Study information
Verified date April 2022
Source Chinese PLA General Hospital
Contact Jiayu Huang, M.S.
Phone +86 17782407581
Email huang_jy_cocacola@163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting osteoarthrosis. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.

Description:

7T MRI increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3T MRI. When applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. This study aim to detect the image characteristics and diagnostic accuracy of osteoarthrosis on 7T MRI.

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date May 31, 2025
Est. primary completion date May 31, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Age=18 and =80 - Having no contraindications against MRI - Clinically stable Exclusion Criteria: - Age#18 or #80 - Pregnancy and other contraindication to MRI scan - Informed consent not obtained

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Magnetic resonance imaging
Patients recruited will receive Magnetic resonance imaging.

Locations
Country Name City State
China Chinese PLA General Hospital Beijing

Sponsors (1)
Lead Sponsor Collaborator
Chinese PLA General Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary The thickness of the cartilage of patellar on 7T MRI scan Thickness of different part of the cartilage of patellar measured based on axial PD images baseline
Primary The T2 mapping value of the patellar cartilage on 7T MRI scan T2 relaxation times of the patellar cartilage measured based on T2 mapping baseline
Primary The abnormal signal in the infrapatellar fat pad The exist of abnormal signal in the infrapatellar fat pad detected based on sagittal PD images baseline
Secondary Signal change of the patellar chondral before and after rehabilitation The correlation between abnormal change of the patellar chondral and reaction 1 month after rehabilitation 1 month after rehabilitation
Secondary Signal change of the infrapatellar fat pad before and after rehabilitation The correlation between abnormal signal in the infrapatellar fat pad and reaction 1 month after rehabilitation 1 month after rehabilitation
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