Clinical Trials Logo
  1. Home
  2. MRI
  3. NCT01578694

Characterization of Proteoglycan Depletion in Femoroacetabular Impingement With T1ρ Magnetic Resonance Imaging (MRI)

MRI Clinical Trial

Official title:
Characterization of Proteoglycan Depletion in Femoroacetabular Impingement With T1ρ MRI

Clinical Trial Summary

Magnetic resonance imaging (MRI) has proven to be one of the best ways to image articular cartilage. A tremendous amount of research has focused on cartilage imaging with an emphasis of early-osteoarthritis (OA) characterization. One of the techniques which has shown great promise is the imaging technique called T1ρ . The advantage of this pulse sequence is that it is sensitive to proteoglycans (PG), a major macromolecule degraded in OA. The study objective is to determine if T1ρ can acutely assess PG content in femoroacetabular impingement (FAI) which may allow physicians to differentiate between normal and early-OA cartilage states in FAI patients.

Clinical Trial Description

Magnetic resonance imaging (MRI) is one of the best ways to image articular cartilage. One of the techniques which has shown great promise is the imaging technique called T1ρ (T1-rho). T1ρ is a modified pulse sequence from the standard T1 sequence used in the clinical MRI. Because the initial phases of arthritis occur at the molecular level, the main advantage of the T1ρ pulse sequence is that it is sensitive to proteoglycan. Proteoglycan is a molecule that is important to cartilage structure, and is lost as osteoarthritis develops. If we can show that this non-invasive tool can accurately assess cartilage damage and levels of proteoglycan, the clinical applications are numerous. The results can potentially help determine optimal surgical techniques and timing of surgical intervention to halt or slow the progression of arthritis, and will assist in the study of the effects of FAI and the success of the surgery performed to correct FAI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01578694
Study type Interventional
Source Ottawa Hospital Research Institute
Contact
Status Completed
Phase N/A
Start date July 2007
Completion date December 2012
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05036629 - Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects N/A
Completed NCT02548819 - University Hospital Cardiac Device MR Registry: The Safety of MR Imaging in Patients With Implanted Cardiac Devices N/A
Completed NCT01168479 - FLAME: Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer Phase 3
Completed NCT00512226 - Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia N/A
Recruiting NCT05439330 - Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning N/A
Not yet recruiting NCT05464576 - Tumor Staging T of Bladder Tumours: Correlation of MRI and Anatomopathologic Analysis N/A
Recruiting NCT04034667 - Study of CT and MR in the Lung Cancer
Recruiting NCT04028375 - Study of CT and MR in the Gastric Cancer
Recruiting NCT04231175 - Dedicated MR Imaging vs Surgical Staging of Peritoneal Carcinomatosis in Colorectal Cancer N/A
Completed NCT00949507 - Comparison of Two Regimens of Anesthesia for Children Undergoing Magnetic Resonance Imaging (MRI) in General Anesthesia Phase 4
Completed NCT01420211 - Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist® Phase 1/Phase 2
Recruiting NCT05167669 - Pain Relief in Symptomatic Bone Metastases With Adjuvant Hyperthermia MR Guided HIFU Early Phase 1
Recruiting NCT05618990 - OPTIMIZATION of ADVANCED MR SEQUENCES
Recruiting NCT05107232 - OSV-IRM - Volunteer MRI Sequence Optimization N/A
Completed NCT00556101 - Patient Acceptance of Whole Body Magnetic Resonance Angiography N/A
Recruiting NCT03142698 - Evaluation of 4 MRI Methods (PDFF 3, 6 and 11 Gradient Echoes and Spectroscopy) Compared to the Reference Method (Liver Biopsy) in Quantification of Hepatic Steatosis N/A
Suspended NCT00554073 - Whole Body Magnetic Resonance Angiography in Ischemic Patients at 1.5 and 3T N/A
Completed NCT06366906 - 10-year Retrospective Study of Oral and Maxillofacial Squamous Cell Carcinoma
Not yet recruiting NCT05359497 - Value of MRCP+ And Liver Multiscan in the Management of Dominant Strictures in Primary Sclerosing Cholangitis N/A
Recruiting NCT05192629 - Intranasal Dexmedetomidine Versus Oral Midazolam as Premedication for Propofol Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging Phase 3