Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging

MRI Scans Clinical Trial

Official title: Comparison of New MRI Methods for Quantitative Assessment of Myocardial Perfusion With Quantitative PET Perfusion Imaging

Status Withdrawn

Clinical Trial Summary

This work seeks to develop, evaluate and use new MRI methods for non-invasive quantitative assessment of myocardial perfusion and perfusion reserve (MPR), and to compare with quantitative PET imaging.

Clinical Trial Description

This project aims to determine the validity of quantitative MRI perfusion methods by comparison with quantitative PET imaging. First pass dynamic contrast enhanced MRI scans will be performed at rest and during hyperemia caused by either adenosine infusion or regadenoson. After custom reconstruction and post-processing the data will be fit to a compartment model and quantitative perfusion and MPR values obtained.

On another day, the subjects will have quantitative PET imaging with O-15 labeled radioactive water. This will be done at rest and hyperemia caused by either adenosine or regadenoson. A low dose CT scan will be acquired to perform attenuation correction of the PET images. The images will be reconstructed and processed as reported in the literature to provide reference standard perfusion and MPR values. These values will be compared with those obtained by MRI. ;

Related Conditions & MeSH terms

• MRI Scans

• NCT number: NCT02608944
• Study type: Interventional
• Source: University of Utah
• Status: Withdrawn
• Phase: N/A
• Start date: September 30, 2012
• Completion date: June 12, 2019