MPV Clinical Trial
Official title:
Platelet Indices ( Platelet Count - Mean Platelet Volume - Platelet Distribution Width ) in Decompensated Post Hepatitic Liver Cirrhosis
The aim of the present work is to study platelet indices ( platelet count - mean platelet volume - platelet distribution width ) as noninvasive predictors in decompensated post hepatitic liver cirrhosis .
Cirrhosis is an advanced liver disease characterized by fibrosis and alteration in hepatic
architecture with the development of structurally anomalous nodules . Ascites is a condition
in which pathological collection of fluid occurs within the peritoneal cavity mainly because
of portal hypertension. It is a major complication of liver cirrhosis, The appearance of
ascites in cirrhotic patients indicates a poor prognosis , Spontaneous bacterial peritonitis
is a severe infection, commonly occurring in cirrhotic ascitic patients.
Platelets are attributed to preserve hemostasis. Yet, recently, there has been growing
recognition that they also play an essential role in inflammatory and immune response.
Platelets release prothrombotic and proinflammatory agents and participate in the induction
and advancement of vascular and inflammatory disorders . Larger-sized platelets contain many
granules, and are therefore more efficient in their hemostatic and proinflammatory actions .
This is why the mean platelet volume (MPV) and platelet distribution width (PDW) are worth
considering as potential tests for platelet function and activation .
The MPV and PWD can be calculated using almost all automated hematology analyzers. The MPV
indicates the average platelet size in femtoliters. The PDW, reflecting homogeneity of
platelet size, is calculated from the MPV by the equation (SD of platelet volume divided by
MPV×100) or the distribution width at 20% frequency .
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