Vestibulo-Ocular Reflex Function in Individuals With Chronic Motion Sensitivity Cross-Sectional Study

Motion Sickness Clinical Trial

Official title:

Vestibulo-Ocular Reflex Function in Individuals With Chronic Motion Sensitivity Cross-Sectional Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06128707
• Other study ID #: IRB# 5230167
• Status: Recruiting
• Start date: September 30, 2023
• Est. completion date: September 2024

Study information

• Verified date: April 2024
• Source: Loma Linda University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Chronic motion sensitivity refers to a sensation of unwellness caused by physical or discerned motion and has a prevalence of 28% in the general population and it is more common in women (27.3%) compared to men.

The investigators theorize that individuals with chronic motion sensitivity will have an impaired inner ear reflex and will be less physically active. Hence, the purpose of this study is to;

1. Determine whether the function of an inner ear reflex is different between young adults with/without chronic motion sensitivity

2. Assess relationships between reflex function and balance in young adults with/without CMS

3. Assess relationships between physical activity and balance in young adults with/without CMS.

Description:

Chronic motion sensitivity (CMS), also known as motion sickness, refers to a sensation of unwellness caused by physical or discerned motion. CMS has a prevalence of 28% in the general population and it is more common in women (27.3%) compared to men.

Based on established evidence that individuals with chronic motion sensitivity demonstrate impaired postural stability with vestibular system impairment adjudged to be an inciting stimulus for chronic motion sensitivity, and individuals who practiced more physical and sporting activities have less motion sickness susceptibility than individuals who did not, the investigators theorize that individuals with chronic motion sensitivity will have an impaired inner ear reflex, causing them to be more reliant on other sensory systems like their muscles and joints, and their vision, we also theorize that individuals who are physically active will be less susceptible to chronic motion sensitivity.

The purpose of this study is to;

1. Determine whether the function of an inner ear reflex is different between young adults with/without chronic motion sensitivity

2. Assess relationships between reflex function and balance in young adults with/without CMS

3. Assess relationships between physical activity and balance in young adults with/without CMS.

Participants between the age of 20 and 40 with and without a self-reported history of chronic motion sensitivity (i.e, experiencing nauseousness and/or dizziness during while using various means of transportation such as, car, train, bus, boat, and airplane and/or, recreational fun-fair rides and/or when exposed to conflicting visual images). Participants will be excluded if they report a medical diagnosis of central nervous system disorder, impaired cervical spine range of motion, migraines, seizure disorder, vestibular dysfunction, or any musculoskeletal dysfunction that can limit their participation in the study.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: September 2024
• Est. primary completion date: September 2024
• Gender: All
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Age 20-40

• With and without a history of CMS

Exclusion Criteria:

• CNS disorder

• Impaired cervical spine ROM

• Migraines

• Seizures

• Vestibular dysfunction

• Musculoskeletal dysfunction

• Medications causing dizziness

Related Conditions & MeSH terms

• Hypersensitivity
• Motion Sickness

Locations

Country	Name	City	State
United States	Loma Linda University	Loma Linda	California

Sponsors (1)

Lead Sponsor	Collaborator
Loma Linda University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Motion sickness susceptibility questionnaire short form	Questionnaire used to asses motion sickness susceptibility	1 day
Primary	Bertec vision advantage	Scores on 4 parametters- Baseline visual acuity (Logarithm of the minimum angle of resolution LogMAR)- A measure of optotype size with lower values signifying smaller optotype size and better vision with the head static, Visual processing time (Mili seconds) this is the time taken to identify the size of the optotype, Dynamic visual acuity (Logarithm of the minimum angle of resolution LogMAR)-A measure of optotype size with lower values signifying smaller optotype size and better vision with the head dynamic, Gaze stability test (Degrees per second), this is the highest speed at which the participant can identify the optotype while the head is moving.	1 day
Primary	Computerized dynamic posturography with immersion virtual reality	Average scores under 2 conditions- Condition one- Eye open, Stable platform, Condition 2 Eye open, sway referenced platform. Each condition measured gives a score known as the equillibrum score measured as age matched normative data with higher scores signifying stronger balance , and a lower scores signifying weaker balance	1 day
Secondary	International Physical activity questionaire short form	Questionaire to assess physical activity	1 day