Measles Vaccination at Health System Contacts

Status Enrolling by invitation

Clinical Trial Summary

In addition to protecting against measles infection, measles vaccine (MV) strengthens the individual's ability to combat infections in general - MV has beneficial non-specific effects (NSE) lowering the risk of death and admissions by around 30%. In Guinea-Bissau 30% of children do not receive a routine MV scheduled at 9 months of age, putting both the individual child's health and measles eradication at risk. WHO recommends vaccination at health system contacts, including those for curative services. At the paediatric ward of the national hospital in Guinea-Bissau, there are more than 2600 yearly contacts with measles-unvaccinated children aged 9-59 months, but no vaccines are given. In a randomised controlled trial, we will assess the effect of providing MV vs placebo to 5400 children at hospital contacts (at discharge or after an out-patient consultation) to test the hypothesis that MV reduces the risk of admission or death (composite outcome) by 25% over the subsequent 6 months.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Hospital Admission
Measles
Measles Vaccine
Mortality
Non-specific (Heterologous) Effects of Vaccines

Clinical Trial Details

NCT number	NCT04220671
Study type	Interventional
Source	Bandim Health Project
Contact
Status	Enrolling by invitation
Phase	Phase 4
Start date	January 8, 2020
Completion date	August 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04507867` - Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III	N/A
Completed	`NCT04092465` - Outcomes of Surgical Resection After Induction Treatment in Non-Small Cell Lung Cancer (SRaIT)
Completed	`NCT03296423` - Bacillus Calmette-guérin Vaccination to Prevent Infections of the Elderly	Phase 4
Not yet recruiting	`NCT04900610` - The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis	N/A
Completed	`NCT04149873` - Effectness of Treatment With Mechanical Insufflation-Exsufflation	N/A
Completed	`NCT05905042` - Follow-up of Recovery Condition in Survivors of Acute Respiratory Distress Syndrome
Completed	`NCT00527774` - Effect of HCV Infection on Insulin Resistance and Malnutrition-inflammation Complex Syndrome in Regular Hemodialysis Patients	N/A
Completed	`NCT00518856` - Lufwanyama Neonatal Survival Project	N/A
Completed	`NCT06408636` - Prognostic Role of LA Strain in Acute Myocardial Infarction
Completed	`NCT06051526` - The African Critical Illness Outcomes Study
Recruiting	`NCT05055089` - Short- and Medium-term Results of New Generation Aortic
Active, not recruiting	`NCT04132492` - AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients
Completed	`NCT03885206` - Effectiveness and Clinical Outcomes of Municipal Acute Wards Versus a General Hospital	N/A
Completed	`NCT05573659` - Capillary Refill Time Calculated With a Video-assisted Method Has a Better Reproducibility Than Visual Method in Critically Ill Patients	N/A
Withdrawn	`NCT03245658` - The Effect of Cannabis in Pancreatic Cancer	Phase 2
Recruiting	`NCT04094428` - Burden, Mortality and Supply Costs in Intensive Care Unit Patients
Completed	`NCT01631799` - Outcome of Patients After Total Knee Replacement: A Comparison of Femoral Nerve Block and Epidural Anesthesia	N/A
Completed	`NCT00244673` - Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination	Phase 4
Completed	`NCT03378843` - Spermidine Intake and All-cause Mortality	N/A
Recruiting	`NCT04424511` - Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali	Phase 3