Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine

Status Completed

Clinical Trial Summary

The aim of this study is to the effect of opioid (morphine) intradermal application on histaminergic and non-histaminergic itch. In particular, we would like to demonstrate that also peripheral administration of morphine may affect mast cell release of histamine.

Clinical Trial Description

Opioids (i.e. substances extracted from opium poppies, e.g. morphine) are used for treatment of both acute and chronic pain conditions as well as in surgical procedures. Opioids render effective pain relief, however, they may cause bothersome itch as a side effect. With this series of experiments, we wish to clarify how an injection with morphine in the skin layer called dermis (located right below the upper skin) will affect itch. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04672382
Study type	Interventional
Source	Aalborg University
Contact
Status	Completed
Phase	N/A
Start date	July 1, 2021
Completion date	December 31, 2022

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