Mathematical Modeling and Risk Factor Analysis for Mortality of Sepsis

Morality Clinical Trial

Official title:

Mathematical Modeling and Risk Factor Analysis for Mortality of Sepsis Based on Real World Data in China

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03883061
• Other study ID #: 20190319
• Status: Recruiting
• Start date: January 1, 2017
• Est. completion date: December 31, 2021

Study information

• Verified date: January 2021
• Source: Shanghai Tongji Hospital, Tongji University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The purpose of this study was to investigate the risk factors for mortality of sepsis and to create mathematical models to predict the survival rate based on electronic health records that extracted from hospital information system. More than 1000 records should be collected and used to data analysis. Univariate and multivariable logistic regression model were applied to risk factors analysis for the outcome, and machine learn algorithms were employed to generate predictive models for the outcome.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2000
• Est. completion date: December 31, 2021
• Est. primary completion date: March 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 14 Years to 99 Years

Eligibility

Inclusion Criteria:

• all records with sepsis in emergence department of hospitals

Exclusion Criteria:

• subjects with major missing data

Related Conditions & MeSH terms

• Morality
• Predictive Model
• Risk Factor, Sepsis
• Sepsis
• Toxemia

Intervention

Other:
• regular medical treatment
regular medical treatment

Locations

Country	Name	City	State
China	Zihui Tang	Shanghai

Sponsors (7)

Lead Sponsor

Collaborator

Shanghai Tongji Hospital, Tongji University School of Medicine

Department of Biomedical Informatics and Statistics, Insitute of Integrative Medicine, Fudan University, Shanghai, China, Department of emergence, Huaihua people's hospital, Huaihua, Hunan, China, Department of emergence, Hunan people's hospital, Changhai, Hunan, China, Department of Emergence, The First Hospital Affiliated to South China University, Hengyang, Hunan, China., Department of emergence, The hospital affiliated to Jining medical college, Jining, Shandong, China, Department of Integrative Medicine, Huashan Hospital of Fudan University, Shanghai, China

Country where clinical trial is conducted

China, 

References & Publications (1)

Lu Y, Tang ZH, Zeng F, Li Y, Zhou L. The association and predictive value analysis of metabolic syndrome combined with resting heart rate on cardiovascular autonomic neuropathy in the general Chinese population. Diabetol Metab Syndr. 2013 Nov 17;5(1):73. doi: 10.1186/1758-5996-5-73. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	mortality of sepsis	mortality of sepsis	4 weeks