Monkeypox Clinical Trial
Official title:
Viral Clearance and Epidemiological Characteristics in Patients With Monkeypox
The present observational study has been designed to understand the dynamics of viral clearance amongst patients with confirmed monkeypox, by quantifying monkeypox viral load in different specimens trough time, to better inform decision-making about patient management and isolation guidelines. Also, an immune analysis will be performed in a subset of individuals to describe humoral and cellular responses to monkeypox.
Starting in early May 2022 a large number of cases of Monkeypox have been reported in non-endemic countries. Although initial cases appeared to be linked to travel, the majority of subsequent cases appear to have no travel associated risk factors and these cases have predominantly occurred amongst Men who have Sex with Men (MSM) suggesting autochthonous transmission associated with sexual networks. Monkeypox is known to be transmitted by close contact with skin lesions of infected individuals and/or via droplets. It is known that the virus can be detected from skin lesions, in blood, in throat swabs and on occasion urine samples. There is limited information as to whether the virus can be detected or persist in other sites including semen. Serial virological monitoring has been conducted in a small number of individuals and demonstrates that prolonged shedding for at least 2-3 weeks appears to be relatively common. To help control the current outbreak health authorities have used a number of strategies including identifying and isolating cases of monkeypox combined with contact tracing and limited use of ring-vaccination strategies. Because the number of cases seen outside of endemic areas has previously been limited, there is inadequate data to guide decision-making about the duration of isolation, but this is critical to the management of the current outbreak. The present observational study has been designed to understand the dynamics of viral clearance amongst patients with confirmed monkeypox, by quantifying monkeypox viral load in different specimens trough time, to better inform decision-making about patient management and isolation guidelines. Also, an immune analysis will be performed in a subset of individuals to describe humoral and cellular responses to monkeypox. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05512949 -
Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine
|
Phase 2 | |
Completed |
NCT05976100 -
Study of the Safety, Tolerability, Pharmacokinetics of NIOCH-14 in Volunteers Aged 18-50 Years
|
Phase 1 | |
Recruiting |
NCT05988203 -
A Clinical Study Investigating the Safety and Immune Responses After Immunization With Investigational Monkeypox Vaccines
|
Phase 1 | |
Terminated |
NCT05567939 -
Clinical, Virological, Immunological, Psychosocial and Epidemiological Consequences of Human Monkeypox Virus (ProMPX)
|
||
Active, not recruiting |
NCT05562323 -
Characterization of Vaccine-induced Responses Against Monkeypox (MoVIHvax) An Observational Prospective Cohort Study
|
||
Recruiting |
NCT05534984 -
Study of Tecovirimat for Human Monkeypox Virus
|
Phase 3 | |
Not yet recruiting |
NCT05784038 -
Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX)
|
||
Not yet recruiting |
NCT05745987 -
Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
|
Phase 4 | |
Recruiting |
NCT05879965 -
Prospective Study for the FOLLOW-UP of Human Monkeypox Cases and Smallpox Vaccinees at Risk
|
||
Completed |
NCT03745131 -
Cohort Study of Healthcare Workers Receiving Imvanex®
|
||
Recruiting |
NCT05559099 -
Tecovirimat for Treatment of Monkeypox Virus
|
Phase 2 | |
Completed |
NCT05846243 -
Study on Immunogenicity, Reactogenicity and Safety of the VACΔ6 Vaccine in Volunteers Aged 18-60 Years
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT05629299 -
Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM
|
N/A | |
Recruiting |
NCT05654883 -
New York City Observational Study of Mpox Immunity
|
||
Completed |
NCT05762523 -
Safety and Tolerability Study of the VAC∆6 Vaccine in Volunteers Aged 18-40 Years
|
Phase 1 | |
Recruiting |
NCT05597735 -
Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease
|
Phase 3 | |
Recruiting |
NCT05734508 -
Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC
|
Phase 4 | |
Active, not recruiting |
NCT05740982 -
A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox
|
Phase 2 | |
Recruiting |
NCT06045923 -
Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV
|
||
Recruiting |
NCT05947786 -
Mpox Paediatric and Adolescent Clinical Study
|