Lower Extremity Muscle and Function in the Elderly: Study 2

Mobility Limitation Clinical Trial

Official title:

Lower Extremity Muscle and Function in the Elderly: Study 2

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01614392
• Other study ID #: AG-18844
• Status: Completed
• Phase: N/A
• Start date: September 2009
• Est. completion date: October 2011

Study information

• Verified date: December 2018
• Source: Tufts University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This research study is looking to compare the effects of two uniquely different power training interventions (high force, lower velocity versus low force, high velocity) on changes in mobility status among older individuals at risk for mobility disability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 52
• Est. completion date: October 2011
• Est. primary completion date: October 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 70 Years to 85 Years

Eligibility

Inclusion Criteria:

• Male and Female 70-85 yrs

• Community dwelling

• Short Performance Battery Score >9

• BMI range 19-32 kg/m2

• Willingness to be randomized and come the laboratory for 20 weeks.

Exclusion Criteria:

• Acute or Terminal Illness

• MI in previous 6 months, symptomatic coronary artery disease or congestive heart failure.

• Upper or Lower extremity fracture in previous 6 months

• Uncontrolled hypertension (150/90mmHg)

• Neuromuscular diseases and drugs that affect neuromuscular function

• Hormone replacement therapy

• Participation in any regular endurance or resistance training exercise during previous 3 months

Related Conditions & MeSH terms

• Mobility Limitation

Intervention

Behavioral:
• High velocity low force Power Training
Lower Extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).
• Low velocity high force Power Training
Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).

Locations

Country	Name	City	State
United States	Jean Mayer USDA Human Nutrition Research Center on Aging	Boston	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
Tufts University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Leg Extensor Muscle Power	Leg extensor muscle power measured on pneumatic strength testing equipment at a external force consistent with 70% of the participant maximum leg extensor strength.	Change from baseline to Week 16