Mitral Regurgitation Clinical Trial
Official title:
Impact of Acute Normovolemic Hemodilution on Whole Blood Coagulation Profile During Post-cardiopulmonary Bypass in Cardiac Surgery: Rotational Thromboelastometry Study
Impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before initiating
cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not been well
established.
Patients undergoing cardiac surgery employing moderate hypothermic CPB (n=40) are randomly
allocated into one of two groups: in Group-ANH(n=20), ANH is applied by using a balanced
hydroxyethyl starch (HES 130/0.6); and in Group-C, ANH is not applied.
After weaning from CPB, intergroup differences of INTEM, EXTEM, FIBTEM and APTEM profiles are
analyzed.
As a primary outcome, inter-group difference between maxiaml clot firmness of EXTEM will be
determined at 10 min after ANH in Group-ANH and that at control.
Background: Impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before
initiating cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not
been well established.
Method: Patients undergoing cardiac surgery employing moderate hypothermic CPB (n=40) are
randomly allocated into one of two groups: in Group-ANH(n=20), ANH is applied by using a
balanced hydroxyethyl starch (HES 130/0.6); and in Group-C ANH is not applied.
Intergroup differences of INTEM, EXTEM, FIBTEM and APTEM profiles are analyzed. after
anesthesia induction (control) and after weaning form CPB and protamine neutralization
(after-CPB) in both groups. In Group-ANH, those are determined after ANH (after-ANH).
As a primary outcome, inter-group difference between maxiaml clot firmness of EXTEM is
determined at 10 min after ANH in Group-ANH and that at control.
As secondary outcomes, intergroup differences of Hematocrit (Hct), Na+, K+, HCO3-, Ca2+,
osmolarity, s-Cr are determined Intergroup difference of data at T2 are performed.
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