Examining the Impact of Blood Flow Restricted Aerobic Exercise on PGC-1α

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Clinical Trial Summary

This crossover study investigates the effects of restricting arterial blood flow during cycling exercise on PGC-1α and its upstream signalling pathways. In a randomized order, participants will exercise once for 30 minutes with restricted blood flow and then will exercise once for 30 minutes with no blood flow restriction.

See also
Status	Clinical Trial	Phase
Completed	`NCT04151095` - Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults	N/A
Recruiting	`NCT03975777` - Time-course of Mitochondrial Biogenic Gene and Protein Expression in Exercised Human Skeletal Muscle	N/A
Terminated	`NCT01727167` - CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle	Phase 1/Phase 2

NCT number	NCT03717948
Study type	Interventional
Source	Queen's University
Contact
Status	Completed
Phase	N/A
Start date	October 1, 2018
Completion date	January 28, 2019

Examining the Impact of Blood Flow Restricted Aerobic Exercise on PGC-1α mRNA Expression in Young Healthy Males

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms