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Vagal Nerve Stimulation in Coma Patients — SNV  

Minimally Conscious State Clinical Trial

Official title:
Vagus Nerve Stimulation in Patients With Chronic Consciousness Disorders

Clinical Trial Summary

Minimally Conscious (MCS) or Vegetative State (VS) are disorders of consciousness which often occur following traumatic brain injury or ischemia. These alterations result most of the time in patients' loss of autonomy and require long years of special care. No efficient therapy to improve patients' consciousness has been found so far. Investigators propose to use vagal nerve stimulation (VNS) to restore cortical activity and patients' embodied self. The investigators' main hypothesis is that VNS will reestablish the thalamo-cortical connectivity leading to an improvement of the consciousness state. To test this hypothesis, investigators will use behavioral measures as well as fMRI, PET scan and EEG to assess brain activity. Patients will be evaluated before and during eight months following implantation of the stimulation device.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02591069
Study type Interventional
Source Hospices Civils de Lyon
Contact Angela Sirigu, PhD
Phone 04 37 91 12 31
Email sirigu@isc.cnrs.fr
Status Recruiting
Phase N/A
Start date October 2015
Completion date January 2021
View Details
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