Innate Immunity Stimulation Via TLR9 in Early AD

Status Recruiting

Clinical Trial Summary

This single-center, double-blind, placebo-controlled study will recruit in total 39 participants with either Mild Cognitive Impairment due to Alzheimer's disease (MCI) or Mild Alzheimer's disease dementia (mild AD). There will be 3 Dose levels. An initial cohort of 13 subjects will be randomized to a Dose level 1 (0.1 mg/kg vs. placebo) lasting 8 weeks. An additional 13 subjects will be recruited and randomized into Dose level 2 (0.25 mg/kg vs. placebo) for 8 weeks and 13 subjects for the last Dose level 3 (0.5 mg/kg vs. placebo) for 8 weeks. The primary objective will be to assess safety and tolerability of CpG 1018.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05606341
Study type	Interventional
Source	NYU Langone Health
Contact	Alok Vedvyas
Phone	212-263-2048
Email	Alok.Vedvyas@nyulangone.org
Status	Recruiting
Phase	Phase 1
Start date	March 13, 2023
Completion date	November 2025

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