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Cognitive Effects and Potential Mechanisms of TBS in Subjects With MCI

Mild Cognitive Impairment Clinical Trial

Official title:
Biomarker-based Prediction of Cognitive Effects and Potential Mechanisms of Theta-burst Stimulation (TBS) in Subjects With Mild Cognitive Impairment (MCI)

Clinical Trial Summary

This study aims to examine the effects and potential mechanisms of theta-burst stimulation (TBS) on cognitive function in individuals with mild cognitive impairment (MCI).

Clinical Trial Description

The investigators apply the NIA-AA criteria to subtype different endophenotypes of biomarker-defined MCI individuals. This is a prospective, open-label clinical trial, and combined functional neuroimaging study of 18F-FDG-PET to further explore the potential mechanisms. A total of 80 MCI patients will be consecutively recruited and be subjected to iTBS for 5 daily interventions per week for two consecutive weeks. Cognitive evaluation will be performed before and immediately after TBS intervention, and 8 weeks after TBS. Data on functional neuroimaging will be also collected before and after TBS protocol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05448768
Study type Interventional
Source Chang Gung Memorial Hospital
Contact
Status Enrolling by invitation
Phase N/A
Start date September 13, 2022
Completion date June 30, 2025
View Details
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