Sound and Music for Mild Cognitive Impairment

Mild Cognitive Impairment Clinical Trial

Official title:

The Power of Sound and Music Interventions for Older Adults With Mild Cognitive Impairment

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05064007
• Other study ID #: IRB00295386
• Secondary ID: R21AG078917
• Status: Active, not recruiting
• Phase: N/A
• Start date: February 1, 2022
• Est. completion date: April 1, 2025

Study information

• Verified date: June 2024
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Emerging studies in humans found that 40 Hz sound induces neural gamma oscillation and enhanced cognitive function in older adults with and without Alzheimer's Disease. We will compare a 40 Hz music intervention to both 40 Hz sound and music alone in a clinical cohort of older adults with mild cognitive impairment.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 30
• Est. completion date: April 1, 2025
• Est. primary completion date: April 3, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 95 Years

Eligibility

Inclusion Criteria:

1. Community-dwelling

2. amnesia mild cognitive impairment

3. Preserved function

4. No dementia

Exclusion Criteria:

1. known diagnosis of schizophrenia or Parkinson's disease;

2. severe hearing impairment;

3. presence of an acute medical or psychiatric condition which would interfere with the subject's ability to follow the study protocol realistically

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Behavioral:
• A: 40 Hz music
The participant will listen to the 40 Hz music playlist one hour each day, 5 days a week for 4 weeks
• B: 40 Hz sound
The participant will listen to the 40 Hz sound playlist one hour each day, 5 days a week for 4 weeks
• C: Preferred music
The participant will listen to the preferred music playlist one hour each day, 5 days a week for 4 weeks

Locations

Country	Name	City	State
United States	Johns Hopkins School of Nursing	Baltimore	Maryland

Sponsors (2)

Lead Sponsor	Collaborator
Johns Hopkins University	National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Cognitive function	Cogstate computerized assessment will be used to measure cognitive function. Higher score represents better cognitive function	Baseline and immediately after the 4-week intervention