Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

Mild Cognitive Impairment Clinical Trial

— MST training  

Official title:

Comparing Mnemonic Strategy With Spaced Retrieval Training in Patients With Mild Cognitive Impairment (B6366-W)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04533204
• Other study ID #: B6366-W-1
• Status: Completed
• Phase: N/A
• Start date: August 1, 2010
• Est. completion date: July 30, 2014

Study information

• Verified date: November 2020
• Source: VA Office of Research and Development
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Description:

Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the "trained" stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 59
• Est. completion date: July 30, 2014
• Est. primary completion date: June 30, 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

-Diagnosis of MCI according to Petersen (2004) criteria, right handed

Exclusion Criteria:

• Diagnosis of other neurological condition,
• active drug/alcohol abuse/dependence,
• moderate-severe depression or other Axis I diagnoses.

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Behavioral:
• mnemonic strategy training
training using mnemonic strategies
• spaced retrieval training
training using spaced retrieval

Locations

Country	Name	City	State
United States	VA Ann Arbor Healthcare System, Ann Arbor, MI	Ann Arbor	Michigan

Sponsors (1)

Lead Sponsor	Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment	Change in memory for 45 trained object location associations	up to 1 month after last training session
Secondary	Change in Accuracy (vs. Baseline) on Novel Object Location Associations	Change in accuracy for novel object location associations using a touchscreen task; distance measured in cm from actual location	up to 1 month after last training session