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NCT04277767 Clinical Trial

The Role of Ophthalmologic Tests and EEG Imaging in Alzheimer's Disease

Mild Cognitive Impairment Clinical Trial

Official title:
The Combination of Ophthalmologic Tests and EEG Imaging as a New Biomarker for Alzheimer's Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT04277767
Other study ID # AD2020
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date September 1, 2022
Est. completion date July 1, 2023

Study information
Verified date March 2021
Source Zhongshan Ophthalmic Center, Sun Yat-sen University
Contact Jin Yuan, phD
Phone 13825141659
Email yuanjincornea@126.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Meantime, EEG resting state has also demonstrated significant change in patients with AD in neuroscience research area. Thus, the combination of these sensitive biomarkers would lead to a potential new biomarker for detection of AD, which has higher specificity and sensitivity.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 60
Est. completion date July 1, 2023
Est. primary completion date February 1, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 50 Years to 70 Years
Eligibility Inclusion Criteria: - Clinical diagnosis of Alzheimer's Disease Exclusion Criteria: - neurologic disorders - psychiatric disorders

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• observational
No intervention

Locations
Country Name City State
China Zhongshan Ophthalmic Center Guangzhou Guangdong

Sponsors (1)
Lead Sponsor Collaborator
Zhongshan Ophthalmic Center, Sun Yat-sen University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary OCT retinal and choroidal thickness retinal structural anatomy 2 days
Primary Retinal Photography vascular caliber use Retinal Photography to detect vascular caliber 2 days
Primary functional connection strength in the brain network record resting-state EEG, use graph theory to calculate the functional connection strength 7 days
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