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The Long-term Impact of a Light Intervention on Sleep and Cognition in Mild Cognitive Impairment

Mild Cognitive Impairment Clinical Trial

Official title:
The Long-term Impact of a Light Intervention on Sleep Physiology and Cognition in Mild Cognitive Impairment

Clinical Trial Summary

To investigate the impact of a long-term light treatment intervention on sleep physiology and memory in mild cognitively impaired and mild Alzheimer's disease patients living at home. The goal is also to measure the impact of the lighting intervention on caregivers' sleep, cognition, depression, and quality of life.

Clinical Trial Description

The current application proposes to investigate the impact of a long-term light treatment intervention on sleep physiology and sleep-dependent cognitive processes in mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) patients. The premise is that older adults, especially those with cognitive impairment, are often in continuous dim light, which leads to circadian misalignment. Circadian misalignment impacts the close relationship between homeostatic and circadian processes, which can reduce memory-related sleep features. The hypothesis is that a lighting intervention technology (LIT), designed to promote circadian entrainment, will improve sleep by aligning the two sleep processes (circadian and homeostatic) and, thus improve cognition. In addition to improving patients' lives, LIT has the potential to reduce the overnight burden on caregivers. Thus, an exploratory goal is to also measure the impact of LIT on caregivers' sleep, cognition, depression, and quality of life. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04073628
Study type Interventional
Source Icahn School of Medicine at Mount Sinai
Contact Barbara Plitnick, BSN
Phone 518-242-4603
Email barbara.plitnick@mountsinai.org
Status Recruiting
Phase N/A
Start date June 14, 2021
Completion date April 2025
View Details
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