Mild Cognitive Impairment Clinical Trial
Official title:
Mechanical Integrity of Memory Systems in Mild Cognitive Impairment
Verified date | May 2024 |
Source | University of Delaware |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will measure brain structure through its mechanical properties, assessed with magnetic resonance elastography, and determine whether it improves with aerobic exercise in older adults with low memory abilities. Additionally, this study will determine if memory abilities improve with exercise and if they are related to brain structure. Overall, this project has the potential to identify how brain health is impacted by exercise in older adults.
Status | Completed |
Enrollment | 36 |
Est. completion date | March 31, 2024 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years to 90 Years |
Eligibility | Inclusion Criteria: - Cognitive function scores consistent with amnestic mild cognitive impairment based on pre-screening evaluation - age 60-90 years - MMSE score >24 at time of initial consent Exclusion Criteria: - major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years) - neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct) - other systemic medical illnesses (e.g. cardiovascular disease, cancer, renal failure, diabetes, chronic obstructive pulmonary disease, liver diseases, hypertension) - current medication use likely to affect CNS functions (e.g. long active benzodiazepines) - failed outcome on the baseline graded exercise test - hypertension (systolic 130+ mmHg OR diastolic 80+ mmHg) from baseline blood pressure measurement - claustrophobia, metal implants, pacemaker or other factors affecting feasibility and/or safety of MRI scanning - concussion within last 2 years and more than 3 lifetime concussions - current smoking (including marijuana) within the past 3 months |
Country | Name | City | State |
---|---|---|---|
United States | University of Delaware | Newark | Delaware |
Lead Sponsor | Collaborator |
---|---|
University of Delaware | Christiana Care Health Services, National Institute on Aging (NIA), University of Illinois at Urbana-Champaign |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Change in brain morphometry | MRI will be used to measure brain morphometry, i.e. volume | Baseline, 12 weeks | |
Other | Change in brain function | MRI will be used to measure brain function, i.e. functional connectivity | Baseline, 12 weeks | |
Other | Change in brain white matter integrity | Diffusion MRI will be used to measure integrity of white matter tracts | Baseline, 12 weeks | |
Other | Change in cognitive function | NIH Toolbox will be used to assess cognitive function across several domains | Baseline, 12 weeks | |
Primary | Change in brain mechanical properties | Investigators are assessing change in brain structure through mechanical properties in response to exercise from baseline to the end of the 12 week program. An MRI scan with magnetic resonance elastography (MRE) will be used to measure properties of brain regions important to memory (e.g. hippocampus). | Baseline, 12 weeks | |
Secondary | Change in relational memory performance | Behavioral memory test will be used to assess relational memory through accuracy on a spatial reconstruction task. | Baseline, 12 weeks | |
Secondary | Change in cardiorespiratory fitness | Graded exercise test will measure cardiorespiratory fitness through volume of oxygen uptake (VO2) | Baseline, 12 weeks |
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