Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities

Mild Cognitive Impairment Clinical Trial

Official title:

Evaluation of Differential Effects of a Computer-based-cognitive Intervention on Cognition Among Elderly With Mild Cognitive Impairment With and Without White Matter Hyperintensities: A Comparative Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03195803
• Other study ID #: LUS2WMH
• Status: Completed
• Phase: N/A
• First received: June 14, 2017
• Last updated: June 20, 2017
• Start date: October 2015
• Est. completion date: April 2017

Study information

• Verified date: June 2017
• Source: Broca Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.

Description:

White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 51
• Est. completion date: April 2017
• Est. primary completion date: April 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of Mild Cognitive Impairment

• With and without white matter hyperintensities

• MRI available or accept to perform one

• No engagement in other cognitive intervention program

Exclusion Criteria:

• Psychiatric and neurological disorders

• History of alcohol or other substance abuse

• Sensory and/or motor deficit affecting the use of a tablet

Related Conditions & MeSH terms

• Cognition Disorders
• Mild Cognitive Impairment

Intervention

Behavioral:
• Computerized Cognitive Stimulation
All participants performed 12-week, 60-minutes twice a week of a computer-based cognitive stimulation program in group-setting, using a tablet with a software with specific training focused on attention, executive and speed processing functions.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Leila DJABELKHIR

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rey Auditory Verbal Learning test	Assessment of verbal learning in episodic memory	Baseline assessment, change from Baseline on Rey Auditory Verbal Learning test at 3 months immediately after intervention and at 3 months follow-up