Cognitive Ability Training in Seniors

Mild Cognitive Impairment Clinical Trial

— CATS  

Official title:

Verbesserung Kognitiver Fähigkeiten im Alter

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02587338
• Other study ID #: Wuerzburg22/15
• Status: Completed
• Phase: N/A
• Start date: May 2015
• Est. completion date: December 2016

Study information

• Verified date: March 2024
• Source: Wuerzburg University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigates the beneficial effects of prefrontal brain stimulation (with transcranial direct current stimulation [tDCS]) during working memory training in seniors with subjective memory impairments.The placebo-controlled double blinded study includes 50 elderly probands which were randomized into verum or sham tDCS.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 38
• Est. completion date: December 2016
• Est. primary completion date: October 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 70 Years

Eligibility

Inclusion Criteria:

• native german speaker
• between 60-70 years old
• subjective memory impairment

Exclusion Criteria:

• psychiatric, neurological diseases
• uncorrected hearing or vision deficits
• actual psychopharmaco intake
• metal parts in the head
• medical electronical implants

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Device:
• Verum tDCS
Neuropsychological (Working memory) training for 30 minutes, 6 sessions tDCS during training with 2000 microampere left anodal, right cathodal
• Sham tDCS
Neuropsychological (Working memory) training for 30 minutes, 6 sessions tDCS during training with 0 microampere

Locations

Country	Name	City	State
Germany	University hospital	Wuerzburg

Sponsors (1)

Lead Sponsor	Collaborator
Wuerzburg University Hospital

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neuropsychological Performance in Neuropsychological Test: Verbal Learning Memory Test (VLMT)	The Investigators are measuring cognitive performance for different executive functions, here the score (percentile of the norm values) of the test verbal learning memory test (VLMT), parameter immediate recall post treatment is reported. Rage from 0 to 100 %. Higher values indicate higher performance.	4 weeks
Secondary	Brain Activation Measured With Near-infrared Spectroscopy (NIRS) During the Semantic Condition of the Verbal Fluency Task (VFT)	NIRS is a brain imaging method, with the parameters of oxy (OxyHB) and deoxy (deoxyHB) hemoglobin. Activation is reflected by increase of OxyHB and decrease DeoxyHB. Differences from pre- to post-measurement for OxyHB are reported in a region of interest analysis of the dorsolateral prefrontal cortex.	4 weeks