Mild Cognitive Impairment Clinical Trial
Official title:
Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults With Mild Cognitive Impairment
Verified date | October 2019 |
Source | University of Rochester |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training. In addition, this project aims to identify physiological factors that may bolster effects of the training on cognitive function. Individuals with MCI are at high risk for Alzheimer's disease (AD). Understanding how cognitive training protects cognitive function in MCI can contribute to development of effective interventions to slow progression to AD in individuals at risk, thereby reducing the significant morbidity and health care costs associated with AD.
Status | Completed |
Enrollment | 84 |
Est. completion date | July 1, 2019 |
Est. primary completion date | October 9, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years and older |
Eligibility |
Inclusion Criteria: - a clinical diagnosis of "mild cognitive impairment due to Alzheimer's disease" using the most recent NIA and Alzheimer's Association workshop criteria within 3 months: a) must have memory deficit (1-1.5SD below age- and education-corrected population norms); b) may have deficits in other cognitive domains (e.g., executive function); c) preserved BADL, defined as requiring occasional assistance on less than two items on the Minimum Data Set-Home Care interview, d) absence of dementia using NINCDS-ADRDA criteria; - if on AD medication (i.e., memantine or cholinesterase inhibitors), no changes of doses in the 3 months prior to recruitment; - capacity to give consent based on clinician assessment; and - other: age =60 years, English-speaking, adequate visual acuity for testing, and community-dwelling. Exclusion Criteria: - current enrollment in another cognitive improvement study; - major depression: 15-item Geriatric Depression Scale scored > 7; - MRI contraindications, e.g., metallic implant, pacemaker, claustrophobia; and - major vascular diseases: stroke, myocardial infarction, congestive heart failure. |
Country | Name | City | State |
---|---|---|---|
United States | University of Rochester Memory Care Program | Rochester | New York |
Lead Sponsor | Collaborator |
---|---|
University of Rochester | National Institute of Nursing Research (NINR) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | long-term visual memory | long-term visual memory will be assessed using Brief Visuospatial Memory Test (BVMT)-R. | change from baseline to 6-month follow-up | |
Primary | Attention and processing speed test (UFOV) | change from baseline to 6-month follow-up | ||
Secondary | Cognitive control and working memory (EXAMINER) | change from baseline to 6-month follow-up | ||
Secondary | instrumental activities of daily living (TIADL) | change from baseline to 6-month follow-up | ||
Secondary | mean of functional connectivity in default mode network | Resting state fMRI will be used to assess the functional connectivity of the neural network. SPM will be used to analyze and determine the change of the connectivity over time. | change from baseline to 6-month follow-up | |
Secondary | mean of structural connectivity in default mode network | Diffusion tensor imaging will be used to assess the structural connectivity of the neural network. FSL will be used to analyze and determine the change of the connectivity over time. | change from baseline to 6-month follow-up |
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