Mild Cognitive Impairment Clinical Trial
— CoCoTAOfficial title:
Effectiveness of Computerized Cognitive Training Apparatus (CoCoTA) in the Elderly With Normal Cognition, Subjective Cognitive Impairment, Mild Cognitive Impairment
NCT number | NCT02480738 |
Other study ID # | 10035434 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 2012 |
Est. completion date | July 2013 |
Verified date | May 2019 |
Source | Seoul National University Bundang Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study is to investigate the effectiveness of computerized cognitive training, and corresponding neural substrates through multimodal neuroimaging assessment, in the elderly with normal cognition, subjective cognitive impairment, and mild cognitive impairment.
Status | Completed |
Enrollment | 26 |
Est. completion date | July 2013 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 51 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Ages >50 to =70 - Years of education = 6 years - No physical barrier preventing the dominant hand from using the computer mouse Exclusion Criteria: - Subjects who had any structural lesions or psychiatric disorders that explained the memory deficits - Subjects had to be able to undergo pre- and post-training evaluations such as electroencephalography (EEG), FDG-PET, and magnetic resonance imaging (MRI) - Subjects who had scalp lesions, severe back pain, or claustrophobia that precluded pre- and post-training evaluations. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Bundang Hospital |
Na HR, Lim JS, Kim WJ, Jang JW, Baek MJ, Kim J, Park YH, Park SY, Kim S. Multimodal Assessment of Neural Substrates in Computerized Cognitive Training: A Preliminary Study. J Clin Neurol. 2018 Oct;14(4):454-463. doi: 10.3988/jcn.2018.14.4.454. Epub 2018 J — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical improvement in the follow-up neuropsychological tests | changes in memory and frontal domain subscores between the baseline and follow-up | 12 weeks | |
Secondary | Cortical thickness changes between baseline and follow-up volumetric MRI | surface-based morphometry using freesurfer software | 12 weeks | |
Secondary | White matter integrities changes between baseline and follow-up diffusion tensor imaging | tract-based spatial statistics using fsl software | 12 weeks | |
Secondary | Spectral ratio changes between baseline and follow-up EEG | EEG spectral ratio analysis | 12 weeks | |
Secondary | local activation pattern changes between baseline and follow-up Fludeoxyglucose PET | local activation pattern analysis using SPM | 12 weeks |
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