Mild Cognitive Impairment Clinical Trial
Official title:
Effectiveness of Computerized Cognitive Training Apparatus (CoCoTA) in the Elderly With Normal Cognition, Subjective Cognitive Impairment, Mild Cognitive Impairment
This study is to investigate the effectiveness of computerized cognitive training, and corresponding neural substrates through multimodal neuroimaging assessment, in the elderly with normal cognition, subjective cognitive impairment, and mild cognitive impairment.
Computerized cognitive training has the advantage of easy accessibility for
community-dwelling elderly. It can be much cheaper than traditional neuropsychological
training methods, which require trained neuropsychologists. Furthermore, it may be more fun
and easier to be optimized to an individual patients' cognitive status than other traditional
methods.
Clinical efficacy of these kinds of cognitive training applications has been validated
through several studies. A recent systematic review reported that the domains of working
memory, executive function, and processing speed benefited the most by classic computerized
cognitive training tasks, and that these benefits were comparable with traditional cognitive
training methods. Apart from neuropsychological data, neuroimaging studies focusing on the
effectiveness of computerized cognitive training are scant.
There have been no previous studies investigating the possible neural substrates of
computerized cognitive training using multimodal neuroimaging modalities simultaneously.
Thus, we aimed to investigate the effectiveness of computerized cognitive training and
corresponding neural substrates in subjects with mild cognitive impairment, subjective memory
impairment, and normal controls through a multimodal approach.
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