Mild Cognitive Impairment Clinical Trial
Official title:
Can Methylphenidate (Ritalin) Improve Memory and Attention in Mild Cognitive Impairment? A Combined Behaviour-EEG Study
Traditionally, memory impairments in the elderly population are treated using cholinesterase
inhibitors, although impairments remain after treatment. Dopamine (DA) is also involved in
cognition and is especially of interest in healthy ageing because of the role in processing
speed and cognitive control. To what extent dopamine treatment improves memory and attention
in older impaired individuals is unknown. However, such an effect is conceivable because of
the close relationship between memory and attention in aging and since improved processing
speed and cognitive control may lead to improved memory.
The investigators aim to examine, in the impaired older population, whether a treatment
using methylphenidate, a DA re-uptake inhibitor that enhances DA, improves attention and
memory. The study will be conducted according to a cross-sectional, double-blind,
placebo-controlled, 2-way cross-over design. 20 male and female patients with Mild Cognitive
Impairment (MCI), amnestic type, aged above 60 years of age; 20 male and female patients
with MCI, non-amnestic type, will be recruited from the Orbis Medical Centre. Participants
will be treated once with 20 mg methylphenidate (MPH) and once with placebo. All medications
will be administered orally with a capsule. The treatment order will be established by
counterbalancing.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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