Mild Cognitive Impairment Clinical Trial
Official title:
Mild Cognitive Impairment:Cerebrovascular Dysfunction and Exercise
This study is being done to find out whether regulation of brain blood flow is altered in
patents with mild cognitive impairment (those who have memory problems but otherwise healthy)
when compared with healthy elderly individuals. In addition, this study will determine
whether exercise training improves brain blood flow, brain structure, and brain function in
patients with mild cognitive impairment (MCI).
This is a research study because at present the investigators know little about brain blood
flow regulation in patients with mild cognitive impairment. The investigators also know
little about whether exercise training improves brain blood flow, brain structure, and brain
function in patients with mild cognitive impairment.
We plan to study 70 patients with amnestic MCI and 30 healthy older adults with similar age,
sex, and educational level in this research at the University of Texas Southwestern(UTSW)
Medical Center Dallas and Texas Health Presbyterian Hospital Dallas - Institute for Exercise
an Environmental Medicine (IEEM).
To help decide if you qualify to be in this study, the researchers may ask you questions
about your health, including medications you take and any surgical procedures you have had.
You may also have to fill out certain forms or have the following exams, tests or procedures.
The screening process usually takes 2-3 hours.
You will be required to come for 7-9 visits including the initial screening for eligibility
to participate in this study. The experiments will measure your brain perfusion, vascular
function and exercise capacity.
For the healthy controls, the expected length of this study will be about 2-3 months
including all the test visits. Your participation in this study will end following completion
of your testing.
For those with Mild Cognitive Impairment, the expected length of this study will be about 18
months including all the test visits and exercise training. Your participation in this study
will end following completion of your repeat testing after one-year exercise training or
control intervention. On occasion, training may be delayed due to injury, illness or personal
matters. If this is the case, your enrollment in the study may last longer than one year as
we attempt to complete the training and testing.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04513106 -
Promoting Advance Care Planning for Persons With Early-stage Dementia in the Community: a Feasibility Trial
|
N/A | |
| Recruiting |
NCT06011681 -
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
|
||
| Recruiting |
NCT04522739 -
Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Alzheimer's Disease
|
Phase 4 | |
| Active, not recruiting |
NCT03167840 -
Falls Prevention Through Physical And Cognitive Training in Mild Cognitive Impairment
|
N/A | |
| Active, not recruiting |
NCT03676881 -
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
|
||
| Not yet recruiting |
NCT05041790 -
A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate Compared to Placebo in Patients With Degenerative Mild Cognitive Impairment
|
Phase 4 | |
| Recruiting |
NCT04121156 -
High Definition Transcranial Direct Current Stimulation (HD-tDCS) in Patients With Mild Cognitive Impairment
|
N/A | |
| Recruiting |
NCT03605381 -
MORbidity PRevalence Estimate In StrokE
|
||
| Completed |
NCT02774083 -
Cognitive Training Using Feuerstein Instrumental Enrichment
|
N/A | |
| Completed |
NCT01315639 -
New Biomarker for Alzheimer's Disease Diagnostic
|
N/A | |
| Enrolling by invitation |
NCT06023446 -
Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?
|
||
| Completed |
NCT04567745 -
Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers
|
Phase 1 | |
| Recruiting |
NCT05579236 -
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
|
||
| Completed |
NCT03583879 -
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
|
N/A | |
| Terminated |
NCT02503501 -
Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease
|
Phase 2 | |
| Not yet recruiting |
NCT03740178 -
Multiple Dose Trial of MK-4334 in Participants With Alzheimer's Clinical Syndrome (MK-4334-005)
|
Phase 1 | |
| Active, not recruiting |
NCT05204940 -
Longitudinal Observational Biomarker Study
|
||
| Recruiting |
NCT02663531 -
Retinal Neuro-vascular Coupling in Patients With Neurodegenerative Disease
|
N/A | |
| Recruiting |
NCT06150352 -
Sleep Apnea, Neurocognitive Decline and Brain Imaging in Patients With Subjective or Mild Cognitive Impairment
|
||
| Recruiting |
NCT03507192 -
Effects of Muscle Relaxation on Cognitive Function in Patients With Mild Cognitive Impairment and Early Stage Dementia.
|
N/A |