Mild Cognitive Impairment Clinical Trial
Official title:
Enhancing Cognition and Functional Independence in Senior Women With Mild Cognitive Impairment: A Randomized Trial of Aerobic vs. Resistance Training
Verified date | October 2017 |
Source | University of British Columbia |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Alzheimer's disease (AD) is a major health issue in Canada; it affects over 8% of the
population aged over 65 years. Persons with AD have a reduced quality of life as they become
dependent on others for activities of daily living (ADLs). This problem of loss of
independence - functional dependence - is one focus of this grant application. It is
projected that by 2020, Canada will have well over 10 million seniors with moderate to severe
functional dependence. Functional dependence was the most significant contributor to an
annual cost of dementia that had already reached $4 billion in the 1990s.
Mild cognitive impairment (MCI) is a well-recognized risk factor for both AD and functional
dependence. Within the broader assessment of cognitive function, the literature suggests that
executive functioning - the ability to concentrate, to attend selectively, to plan and
strategize - is a robust cognitive predictor of functional status in seniors. Specifically,
Royall and colleagues demonstrated executive functioning independently explained 43% of the
functional status in community-dwelling seniors dementia. The researchers will investigate
executive functioning in seniors with MCI.
Randomized trials of various exercise interventions have proven that exercise has many
systemic benefits. Data are emerging that physical activity may improve cognition -
specifically executive function - in healthy adults. The researchers' own pilot data suggest
that resistance training in seniors may improve executive functioning as assessed by
neuropsychological tests and neuro-imaging. However, at present the Cochrane Database of
Systematic Reviews indicates there are insufficient published data to guide exercise
prescription to prevent AD. In persons with MCI, no published studies have reported on
whether physical activity can improve executive function, or delay its decline and thus,
prevent or delay the onset of functional dependence (and later, dementia).
Therefore, among seniors with MCI, the researchers will investigate whether or not specific
exercise prescription can: 1) provide absolute or relative improvement in cognitive function,
particularly executive function; and 2) help maintain functional independence. This will
facilitate the development of effective exercise-based strategies for the prevention of both
cognitive and functional decline in the large population of seniors with MCI - people at
greatly increased risk for AD.
The researchers' proposed research aims to ascertain whether a six-month, twice-weekly
aerobic training (AT) program and a six-month, twice-weekly resistance training (RT) program,
compared with a six-month, twice-weekly stretch & relax (S & R; control) program, will
significantly improve cognition and functional status in community-dwelling women with MCI
aged 70 years and older.
Primary Hypothesis:
At the end of six-month randomized trial, compared with the S & R program, both the AT and RT
programs will significantly improve cognitive performance, as assessed by neuropsychological
testing.
Secondary Hypotheses:
At the end of the six-month randomized trial, compared with the S & R program, participants
of the AT and RT programs will:
1. Demonstrate evidence of cortical plasticity by fMRI, such as increased activation in
cortical regions responsible for item and relational memory; and
2. Will significantly improve their everyday problem solving ability.
Status | Completed |
Enrollment | 86 |
Est. completion date | March 2010 |
Est. primary completion date | August 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 70 Years and older |
Eligibility |
Inclusion Criteria: 1. Community-dwelling senior women; 2. Aged 70 years and older; 3. Subjective memory complaints as determined by interview; 4. MMSE score > 24/30; 5. Scored < 26/30 on the MoCA (74); 6. Visual acuity of at least 20/40, with or without corrective lenses; and 7. Physician approval for participation in an exercise program. Exclusion Criteria: 1. Diagnosed neurodegenerative disease (e.g., AD) and a history of stroke; 2. Have clinically significant peripheral neuropathy or severe musculoskeletal or joint disease; 3. Diagnosed with a psychiatric condition; or 4. Diagnosed with dementia of any type. |
Country | Name | City | State |
---|---|---|---|
Canada | Centre for Hip Health Mobility | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia | Pacific Alzheimer Research Foundation |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cognitive performance after 3 and 6 months of training | 6 months | ||
Secondary | Everyday problem-solving ability after 3 and 6 months of exercise training, brain function after 6 months of training and physical function after 3 and 6 months of training | 6 months |
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