SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days)

Mild Cognitive Impairment Clinical Trial

— SNIFF 120  

Official title:

Therapeutic Effects of Intranasal Insulin Administration in AD

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00438568
• Other study ID #: 30579-B
• Secondary ID: 5R01AG0274151R01
• Status: Completed
• Phase: Phase 2
• First received: February 21, 2007
• Last updated: September 12, 2012
• Start date: June 2006
• Est. completion date: December 2011

Study information

• Verified date: September 2012
• Source: University of Washington
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to find out if insulin, when administered as a "nasal spray" into the nasal passages, improves memory in adults with mild cognitive impairment (MCI) or Alzheimer's disease.

Description:

A growing body of evidence suggests that insulin plays a role in normal memory processes and that insulin abnormalities may contribute to cognitive and brain changes associated with Alzheimer's disease (AD). Interestingly, insulin administered to the nasal cavity is transported within a few minutes into the brain, but does not affect blood sugar or insulin levels.

This study will consist of a randomized double-blind, placebo-controlled parallel group trial in which 90 participants with AD or MCI receive daily intranasal administrations of either insulin (10 or 20 IU twice a day for a total dose of 20 or 40 IU per day) or placebo (saline twice a day) for 4 months. The study will examine the effects of intranasal insulin administration on cognition, cerebral glucose metabolism, and β-amyloid (Aβ) in cerebrospinal fluid (CSF) and plasma, testing the hypothesis that daily intranasal insulin administration for 4 months will facilitate memory for adults with AD, and adults with mild cognitive impairment (MCI). A subset of participants will have the option to participate in 2 sub-studies: PET scans (prior to and at the end of treatment) to determine whether intranasal insulin increases cerebral glucose metabolism; lumbar punctures (LPs) before and at the end of treatment to determine effects of intranasal insulin administration on CSF Aβ levels.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 173
• Est. completion date: December 2011
• Est. primary completion date: December 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Age 55 or greater

• Good physical health

• Memory impairment with a diagnosis of mild cognitive impairment (MCI) or Alzheimer's disease (AD)

• Participants on stable doses of Memantine (Namenda) or cholinesterase inhibitors will be eligible

Exclusion Criteria:

• Chronic sinus problems/allergies with chronic use of nasal decongestants or antihistamines

• Significant neurologic disease that might affect cognition (other than AD), such as stroke, Parkinson's disease, multiple sclerosis, severe head injury with loss of consciousness for more than 30 minutes or with permanent neurologic symptoms

• Significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease

• Preexisting diabetes or current or previous use of hypoglycemic agents or insulin; participants will be excluded if they have a fasting blood sugar greater than 165 on baseline OGTT

• Clinically significant elevations in liver function tests, cholesterol, or triglycerides

• Major psychiatric disorders (e.g., untreated major depression and schizophrenia)

• Chronic use of the following types of medications: anti-psychotic, anxiolytic, and opiates

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease
• Cognition Disorders
• Mild Cognitive Impairment

Intervention

Drug:
• Regular Insulin
administered intra-nasally twice a day for 16 weeks
• Placebo
administered intra-nasally twice a day for 16 weeks

Locations

Country	Name	City	State
United States	Veterans Administration Puget Sound Health Care System	Seattle	Washington

Sponsors (2)

Lead Sponsor	Collaborator
University of Washington	National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

References & Publications (3)

Fishel MA, Watson GS, Montine TJ, Wang Q, Green PS, Kulstad JJ, Cook DG, Peskind ER, Baker LD, Goldgaber D, Nie W, Asthana S, Plymate SR, Schwartz MW, Craft S. Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults. Arch Neurol. 2005 Oct;62(10):1539-44. — View Citation

Reger MA, Craft S. Intranasal insulin administration: a method for dissociating central and peripheral effects of insulin. Drugs Today (Barc). 2006 Nov;42(11):729-39. Review. — View Citation

Reger MA, Watson GS, Frey WH 2nd, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006 Mar;27(3):451-8. Epub 2005 Jun 16. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in cognition		every 8 weeks for 16 weeks, again at 8 weeks post-treatment (24 weeks)	No
Primary	glucose metabolism		every 8 weeks for 16 weeks, again at 8 weeks post-treatment (24 weeks)	No
Primary	plasma biological markers		every 8 weeks for 16 weeks, again at 8 weeks post-treatment (24 weeks)	No
Secondary	CSF biological markers		every 8 weeks for 16 weeks, again at 8 weeks post-treatment (24 weeks)	No
Secondary	cerebral glucose metabolism		every 8 weeks for 16 weeks, again at 8 weeks post-treatment (24 weeks)	No